On the 25th June 2025 the OECD published 56 new, updated and/or corrected test guidelines. The guidelines cover endpoints including; mammalian toxicity and ecotoxicity, and environmental fate.

The guidelines aim to ensure best practices in line with the 3R principles (Replacement, Reduction and Refinement of animal experimentation). The updates will lead to continued 'Mutual Acceptance of Data' across OECD member states and OECD adhering countries.

OECD Human Health Updates

Updates relating to human health endpoint test guidelines include those relating to; eye, skin, immunotoxicity, mutagenicity, repeated dose toxicity, endocrine and reproductive and developmental toxicity endpoints.
 

OECD Environmental Updates

Relating to the environment, updates include a new test guideline for acute toxicity to mason bees, as well as updates to test guidelines relating to acute and early life stage toxicity in fish and toxicity to aquatic plants. Finally, updates to hydrolysis and transformation studies, as well as pesticide residue stability studies have also been issued. 
 

In upcoming posts, the Blue Frog team will dive deeper into the specific changes of these test guidelines, and what it means for regulatory compliance.

Blue Frog Scientific’s team stay abreast of regulatory developments. Using our expertise, we help clients remain compliant and future focussed with their regulatory submissions in a constantly changing regulatory landscape.

If you have any questions relating to the recent updates to the testing guidelines issued by the OECD, call or email and speak with one of our chemical regulatory consultants today.